Pregnenolone:
The "Feel Good" Hormone Everyone Loves!
Can this potent natural supplement boost your vitality
and help reverse symptoms of pre-mature aging?
Pregnenolone, like DHEA, is a natural hormone manufactured in the body. Indeed, pregnenolone is the grand precursor from which almost all of the other steroid hormones are made, including DHEA, progesterone, testosterone, the estrogens, and cortisol. This is why it has been called the "mother hormone."
Despite its powerful metabolites, pregnenolone is widely acknowledged to be without significant side effects.
Boosts Memory and Increases Overall Feeling of Wellness
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"…By its very nature, pregnenolone works with your body to achieve optimal health and longevity. Its many health-enhancing functions underscore its role as one of the most important hormones in the human body. Pregnenolone reduces fatigue and increases endurance. It also provides the brain with the hormonal and neurotransmitter support it needs to reduce memory loss, thus helping to improve concentration and focus. Moreover, it helps those with arthritis, depression, and traumatic injuries…
Clearly, pregnenolone is an essential hormone in people of all ages. The average young adult produces about 14 mg per day. As with other hormones, however, pregnenolone production declines with age. By age 75, the body produces about 60% less pregnenolone than it did at age 35. As the body's supply of pregnenolone diminishes, so does the availability of its other related hormones. This has led scientists to consider pregnenolone usage as a way to turn back the clock on aging and counter the consequences of this dramatic drop in hormone levels…" -- Life Extension Foundation |
What's more, pregnenolone has been widely reported to not only make people smarter but also feel happier due to its well-known mood-heightening qualities.
In medical studies it has been demonstrated to enhance performance on the job and dramatically increase mental alertness while helping to relieve both stress and fatigue simultaneously.
Powerful Anti-Aging Qualities
As is the case with the natural hormone precursor DHEA, pregnenolone levels decline with age. Many physicians and scientists believe that replacement of pregnenolone to youthful levels is an important step in the treatment of pre-mature aging. If you're feeling "older than your days," then pregnenolone may be just what you are looking for.
In fact, pregnenolone may be one of the most important hormones because it seems to have a balancing effect. It is a precursor to many other hormones and scientists say it appears to be able to bring the levels of other important hormones up or down as, needed.
This is why it appears to work equally beneficially for both men and women. Other widely reported benefits of pregnenolone include increased resistance to effects of stress, improvement of mood and energy, reduced symptoms of PMS and menopause, improved immunity, and repair of myelin sheaths (the protective covering around our nerves).
Pregnenolone also operates as a powerful neurosteroid in the brain, modulating the transmission of messages from neuron to neuron, and strongly influencing learning and memory processes.
As with DHEA, pregnenolone levels naturally peak during youth and begin a long, slow decline with age. By the age of 75 our bodies produce 60% less pregnenolone than the levels produced in our mid-thirties. For this reason pregnenolone is one of the biomarkers of aging. Like counting the rings of a tree, by measuring the level of pregnenolone in a person's body at any given point, it is often possible to make an educated guess as to his or her age.
Some other hormones that decline with age are DHEA, the various estrogens, testosterone, progesterone and growth hormone. These are considered biomarkers of aging as well. Since pregnenolone provides the initial raw material from which all these other steroid hormones are made, many scientists believe that it is the decline of pregnenolone that brings about the decline of the others. And while our youth-giving hormones are diminishing, loss of quality-of-life progressively settles in. We slowly begin to experience physical and mental decline; loss of energy, memory loss, visual and hearing impairment, arthritis, cardiovascular disease, and sexual decline, just to name a few.
Supplementing small amounts of pregnenolone is widely reported to help the body increase production of these neuro-hormones, which in turn may help prevent the propensity toward pre-mature aging, improving one's quality of life by rejuvenating the body to more youthful functioning.
A Little History
Research on pregnenolone, as well as usage of pregnenolone, dates back as far as the 1930's. Human studies were conducted in the 1940's on factory workers to test the effects of pregnenolone on fatigue and autoimmune disorders such as rheumatoid arthritis.
The results were highly successful and many significant improvements were noted. Even though pregnenolone was proving to be both safe and effective, research on it was basically discarded when Merck's newly introduced pharmaceutical agent, cortisone, was announced to be a cure-all for rheumatoid arthritis in 1949.
Soon after cortisone and cortisol came into use, the synthetic steroid hormone dexamethasone was introduced, followed by prednisone. Remember, these steroids are hundreds of times more powerful than pregnenolone (or DHEA for that matter). But because they could be patented, it was much more economically advantageous for pharmaceutical companies to promote these drugs rather than pregnenolone.
However, unlike pregnenolone, these synthetic steroidal compounds proved to have some serious side effects, including compromising the immune system and inducing osteoporosis, among others.
Scientists have been studying the impact of hormones on learning and memory for many years. Various studies have found that pregnenolone significantly enhances motivation, the ability to acquire knowledge, and long-term memory. A research group of industrial psychologists conducted studies in the 1940's to test pregnenolone on students and workers for the ability to enhance job performance. They found that the students/workers had a markedly improved ability to learn and remember difficult tasks.
It is also amazing that pregnenolone not only enhanced job performance of the students/workers; but they additionally experienced heightened feelings of well-being. The same research group performed a study on factory workers to see if pregnenolone could improve their work productivity. Productivity increased most notably in the workers whose situations were considered the most stressful; for example, the workers who got paid per piece and whose living depended on their productivity benefited the most from pregnenolone.
Improvement was also noted, but to a lesser extent, in workers who got paid a fixed wage regardless of their productivity levels. Not only did pregnenolone improve productivity for both groups, but the workers also reported enhanced mood.
As previously mentioned, despite incredibly successful results, research on pregnenolone halted in the 1950's when cortisone became available as an immediate cure-all. Because pregnenolone, unlike cortisone, couldn't be patented, pharmaceutical companies had no financial incentive to pursue the research.
It is unfortunate that pharmaceutical companies are governed by a financial system and healthcare system that imposes the requirement that for a molecule to be profitable it must be patentable. If there were half as many studies done on pregnenolone as the patented synthetic drugs we only later learned were harmful, pregnenolone's therapeutic potential would likely be even more far reaching than what is known of it today.
Functions of Pregnenolone
Medical studies demonstrate that pregnenolone shows tremendous potential in an amazing array of illnesses, many of which are associated with pre-mature aging. Promising results have shown that pregnenolone effectively:
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What's more, many leading edge scientists believe this is only the tip of the iceberg. Many years of research are needed just to begin to discover what further miracles can be found. It is believed pregnenolone may also:
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Additionally, according to more recent research pregnenolone may also help:
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According to Dr. Ray Peat, Ph.D, noted hormone researcher and widely quoted author, pregnenolone does not produce a "negative feedback loop."
This means that, unlike some of the synthetic prescription hormones such as testosterone, the use of pregnenolone does not appear to inhibit the body from producing its own stores of the hormone. Indeed, according to Dr. Peat, studies show that oral supplementation of pregnenolone actually enhances the body's ability to make its own pregnenolone naturally!
Pregnenolone Caution
While literally tens of thousands of people throughout the U.S. use pregnenolone with no side effects whatsoever in daily dosages ranging from 25 to 100 mg., a very small handful of people have reported heart palpitations when taking dosages in those high ranges. The heart palpitations generally stop after pregnenolone usage is discontinued.
Therefore, it is best to proceed with caution when first trying pregnenolone, even though this side effect is very rare. This means seeking the supervision of a knowledgeable health care provider first, and using the lowest effective possible dose to start.
On his web site, Dr. Ray Sahelian, M.D. recommends the use of pleasant, cherry-flavored Source Naturals brand chewable pregnenolone tablets in strengths of 10 mg. per tablet. He says, "Take one-tenth to one-half of a tablet under the tongue, as needed. You can break the tablet in small pieces. Do not exceed 5 mg. pregnenolone per day. Do not take more than 2 mg. pregnenolone daily (about a fifth of a tablet) for prolonged periods without medical consultation."
We would add that it is common sense to avoid taking pregnenolone in any dosage range if you experience any kind of negative effects. The same warning goes for any nutritional supplement.
Some pregnenolone users feel more comfortable using it only on an "as needed" basis, for example, when you are stressed, fatigued, depressed, or are experiencing other symptoms known to be relieved by pregnenolone.
Others use it daily. And many experienced users who have already found pregnenolone to be helpful in terms of improved energy levels, mood elevation, stress reduction, arthritis pain relief, enhanced sexual libido, vision improvements, memory improvement, increased stamina and endurance, and have experienced no side effects from using small amounts, often raise their dosage levels anywhere from 10 mg. to 30 mg. or even 50 mg. per day, or higher.
By the way, you may feel comfortable using pregnenolone without your doctor's knowledge. But we strongly recommend telling your doctor about all of your nutritional supplements.
As an added caution, Dr. Sahelian believes that taking time off from regular pregnenolone usage, which he refers to as taking "hormone holidays," will help mitigate any potential unknown risks. Regular users frequently take weekends off. Others take a few weeks off from pregnenolone usage every after 30 days of continuous usage. Check with your doctor to determine what is right for you.
What the Experts Are Saying…
"The most potent memory enhancer yet found."
-- Proceedings of the National Academy of Sciences (Nov. 6, 1995)
"Pregnenolone very quickly helps fatigued, stressed people regain their ability to handle stress, sometimes with a single dose. It also tends to improve function of the thyroid and other glands. It can have a calming effect on the emotions, giving a mood of resilience and an ability to confront challenges. Also, people have noticed that pregnenolone has a "face-lifting" action, produced by improved circulation to the skin, and by an actual contraction of some muscle-like cells in the skin."
-- Dan Milosevich, C.N.
"Pregnenolone…reduces allergic reactions, lessens arthritis inflammation and produces a relaxing and mildly euphoric "stress buffer effect", without any of the negative side effects of cortisol…Pregnenolone improves mood, and has a mild antidepressant effect…[it] also improves energy levels by protecting your energy producing mitochondria from toxins, which would otherwise damage the mitochondria."
-- James South, M.A. (biologist)
"Pregnenolone has been studied extensively since the 1940's…One of its most important actions is to counter damage caused by the natural stress hormone called 'cortisol.' Cortisol is helpful in modest amounts, but is toxic at higher levels. Pregnenolone's ability to block excess cortisol levels may be one of the main reasons for its known memory-enhancing and mood-boosting effects."
-- Dr. Keith Scott-Mumby, MB ChB, MD, PhD, FRCP (MA)
"It is now known that pregnenolone is one of the major hormones in the brain...It protects brain cells from injury caused by stress and fatigue, and an adequate amount has a calming effect on the emotions, which is part of the reason that it protects us from the stress response that leads to an excessive production of cortisone. People feel a mood of resilience and an increased ability to confront challenges."
-- Dr. Ray Peat, Ph.D
"Some people find pregnenolone improves energy levels, vision, memory, clarity of thinking, well-being, and often sexual enjoyment or libido. Pregnenolone may be considered a good brain enhancer in those who are deficient. Studies in rodents show pregnenolone to be one of the most effective and powerful memory boosters. Pregnenolone may increase levels of acetylcholine in the hippocampus and other memory regions in the brain. Some women report lessening of hot flashes or premenstrual symptoms."
-- Dr. Ray Sahelian, M.D.
"Pregnenolone seems to be the most effective bioidentical hormone for memory improvement…As is the case with the steroid-hormone precursor DHEA, pregnenolone levels decline with age. Many physicians and scientists believe that replacement of pregnenolone to youthful levels is an important step in the treatment of aging and symptoms of aging. Pregnenolone may be one of the most important hormones because it seems to have a balancing effect. It is a precursor to many other hormones and may be able to bring the levels of other hormones up or down as needed."
-- Dr. Joseph Mercola, D.O., author The Total Health Program
One Final Important Matter…
The FDA has been making a concerted effort to ban the sales of all hormone-related nutritional supplements. Just over a year ago, they forced the male hormone supplement androstendione off the market, after engaging in a lengthy publicity campaign against it that included publicly embarrassing baseball's home-run king Mark McGuire, by implying his historic home-run hitting streak was the result of taking "anabolic steroids" like androstendione. Of course, androstenedione, also known simply as andro, is not an anabolic steroid. But the truth rarely matters to the bureaucrats when they are on the warpath.
Now the bureaucrats are pressing to take DHEA - one of the most popular natural hormone supplements in the world - off the market. As Dr. William Campbell Douglass reports:
The government might as well drain all the hormones right out of your body. That's basically what they're doing anyway now that DHEA has become the latest in the line of supplements that they're forcing to walk the bureaucratic plank.It's bad enough that you naturally lose this hormone as you age, but if you lose your ability to replace it, suddenly you're up you-know-what creek without a paddle.
The bill before the Senate Bill S. 762, would classify DHEA as an anabolic steroid. Such a classification would land this important naturally occurring hormone on a list of controlled substances, which means you'd no longer be able to get it without a prescription from your doctor.
Someone needs to tell these bozos that DHEA is NOT an anabolic steroid. DHEA is a perfectly safe - and incredibly beneficial hormone. But as with most things, you make less of it as you get older (sometimes as much as 50% less by the time you hit 50 years old) - which makes supplementing with it extremely vital for a significant portion of the population.
We have long predicted that if the bureaucrats were able to force androstendione off the market, their next target would be DHEA, then pregnenolone, then progesterone (helps women balance excess estrogen), and finally melatonin (the popular natural sleep hormone). They simply will not stop until they have relegated these popular natural hormones to the category of prescription drugs, so the multi-billion dollar drug companies can have a monopoly on them.
That's why we urge you to stock up on pregnenolone now, before it is too late. In recent years, the medical bureaucrats in Canada managed to get both DHEA and pregnenolone banned. They are both now considered to be "drugs" in Canada, and you must have a doctor's prescription to obtain them.
Under Senate Bill S. 762 DHEA will probably soon be re-classified as a prescription drug in the U.S. But pregnenolone should be available for at least a short while, unless the bureaucrats intend to interpret Senate Bill S. 762 as banning the sale of pregnenolone also, since it is chemically related to DHEA.
We urge you to act now and stock up on pregnenolone by purchasing from two to 10 bottles while it is still on sale.
Where to Obtain the Very Best Form of Pregnenolone…
Source Naturals brand pregnenolone, in the recommended 10 mg. cherry flavored chewable tablets, is regularly priced at $29.95 per bottle through our recommended vendor, The Silver Edge.
But for the next 10 days only you can order from two to 10 bottles and get them for only $19.95 each. Or, get a single bottle for only $24.95 (60 sublingual tablets per bottle; 10 mg. each; One bottle is more than a month's supply for the average person.)
To order online, simply go to www.thesilveredge.com and click on the "Unique Nutritional Supplements" link.
Or, call the toll-free number below during regular business hours (AZ time), and place your order using your VISA or MasterCard:
1-888-528-0559
Or simply send your check or money order to:
The Silver Edge
PO Box 84910
Phoenix AZ 85071
(Arizona residents must add 8.1% sales tax or the order cannot be processed. Shipping and handling is $7.95 for orders up to $49.95…$9.95 for orders from $50 to $99…or $12.95 for orders from $100 or more.)
P.S. You can order as many additional bottles as you'd like at the special discount price described above, but please be sure to act within the next 10 days! This is strictly a one-time-only "get acquainted" offer, allowing you to stock up on pregnenolone at a steeply discounted price. The Silver Edge currently has only 1,640 bottles of pregnenolone left in stock as of this writing, and they expect to be completely sold out within 10 days, so please do act quickly and decisively if you wish to take advantage of the super low pricing we have arranged for you.
[Special thanks to Life & Health Research Group, Inc., for permission to reprint this excerpt from their upcoming newsletter, The Foss Report on Nutritional Supplements.]
Copyright 2007. No reproduction with the expressed written permission of the publisher. Life & Health Research Group, Inc., PO Box 1239, Peoria AZ 85380.
[Important Notice: These statements have not been evaluated by the Food and Drug Administration and the materials and products mentioned are not intended to diagnose, treat, cure or prevent any disease. Self-treatment is not recommended. All health care decisions should be made under the guidance of an experienced and knowledgeable health care practitioner.]
