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Colloidal Silver and the Deadly
Super-pathogen CRPK
Is colloidal
silver effective against the latest antibiotic-resistant superpathogen
called CRPK, which is proving to be even more deadly than MRSA? I’ve got some good news and some bad news for
you…
A spate of recent news articles have documented the rise of
a new antibiotic-resistant superpathogen known as
CRPK, which stands for Carbapenem Resistant Klebsiella pneumoniae.
Klebsiella
are pathogens that generally infect the urinary tract, blood and tissues. Unfortunately, some strains of Klebsiella
have already been demonstrated to be resistant to all of the usual antibiotic
drugs that were once effective against them.
The
Carbapenems -- a group of “last-resort” antibiotics
for gram-negative bacteria such as Klebsiella – were still effective even
against the antibiotic-resistant forms of Klebsiella, up until August of 2010 when
Carbapenem-resistant forms of Klebsiella
seemed to appear out of nowhere in India and Pakistan.
Later
in 2010, researchers found the drug-resistant bugs had migrated to western Europe by hitching a ride with tourists returning
from South Asia.
Today,
less than a year later, CRPK is being found in as many as 36 states, with
numerous cases being reported in southern California hospitals where
researchers say the infection rate is now “unexpectedly high.”
Indeed,
as of March 2011, 356 cases have already been
found
in Los Angeles area hospitals alone!
Colloidal
Silver and Klebsiela Pneumonia:
Good News and
Bad
The
CRPK form of Klebsiela pneumonia came out of the blue
so quickly, cutting edge researchers haven’t had a chance to study whether or
not silver-based antimicrobials such as colloidal silver are effective against
it.
However,
previous clinical research demonstrates both good news and bad.
The
good news is this: Generally speaking, based
on clinical studies, silver-based antimicrobials are highly effective against
many strains of Klebsiella pneumoniae,
including forms that are often resistant to Big Pharma’s
antibiotic drugs.
But
the bad news is this: At least one
sub-species of Klebsiella has been demonstrated in laboratory studies to become
resistant to silver after repeated
exposure to it.
This
could mean that over time even silver-based antimicrobials might – and I must emphasize
the word might – lose their
effectiveness against the Klebsiella pathogens. Here’s why I emphasize “might”:
What
researchers did was expose a test tube colony of the Klebsiella pathogen grown
in a saline nutrient broth, to small amounts of silver -- just enough to kill
off the weaker pathogens in the colony.
Then
they repeated the process, each time adding a tiny bit more silver than the
last. By the time they did this multiple times (11 separate times in the study
I read, going by memory), the remaining pathogens appeared to be
silver-resistant.
This
was a test-tube study, of course. But it nevertheless demonstrated the
possibility that a subspecies of Klebsiella can actually become
silver-resistant under the right conditions of repeated exposure to a
silver-based product.
Fascinating
Results!
But,
that’s not the whole story. While this particular strain of Klebsiella
appeared to become resistant to silver, its ability to infect people was
nevertheless destroyed!
Here’s
what researcher L.K. Gupta, from the Department of Microbiology, Panjab University, India stated regarding the
silver-resistance developed by a sub-species of Klebsiella, writing in medical
journal Folia Microbiologica:
A silver-resistant mutant of Klebsiella pneumoniae B-5 was
produced by passaging in nutrient broth containing
graded concentrations of silver nitrate up to 150 ppm.
The development of silver resistance in the strain resulted in
rough colonies, decrease in cell size, carbohydrate content and change in klebocin pattern.
The virulence of the AgR strain as
checked by the burn wound model decreased as the mutant could not establish
itself in the skin and spleen of the animals and the organism was cleared more
efficiently by human lymphocytes than the parent AgS
strain.
In
other words, using the B-5 strain of Klebsiella, the researchers were able
produce a strain that was resistant to a silver-based antimicrobial (silver
nitrate).
However,
the silver-resistant strain they developed suffered from a significantly
reduced cell size, and was considerably weaker in virulence (i.e., ability to
cause infection) than the parent strain.
Indeed,
the silver-resistant strain, though alive, could
no longer establish functional infectivity in the skin and spleen of
animals used in the research.
And
the body’s natural immune system processes readily cleared the microbe,
indicating it had been so weakened by the repeated exposure to silver that it
was no longer a significant threat.
Thanks
to the silver, even the pathogens that didn’t die during exposure to silver
still lost their functional infectivity!
More Good
News!
And
there’s even more good news:
Before
medical science discovered the new CRPK form of Klebsiella, clinical research
had found that a whopping 75% of antibiotic-resistant strains of Klebsiella are
stopped cold by silver-based antimicrobials!
Once
again, writing in the medical journal Folia
Microbiologica, researcher N. Kapoor
of the Department of Microbiology, Panjab University,
India, states:
“Multidrug-resistant (MDR) clinical isolates of Klebsiella
pneumoniae were checked for their sensitivity toward silver nitrate by the
tube-dilution method. Nearly 75% of MDR strains could be successfully inhibited
by 5 mg/L of silver nitrate.”
In
other words, the vast majority of the strains of this potentially deadly
pathogen that are no longer killed by the usual prescription antibiotic drugs
have been shown to be inhibited by…(drum roll, please)…antimicrobial silver!
The
fact that silver-based antimicrobials are effective against so many
drug-resistant strains of the Klebsiella pathogen is truly good news,
indeed.
Conclusion
However,
I have to re-emphasize that as of this writing, researchers have not clinically tested the CRPK form of
Klebsiella pneumoniae to see whether or not silver-based antimicrobials are
effective against it.
Hopefully,
medical researchers will take note of the clinical studies mentioned above, and
begin immediate research to determine whether or not silver-based
antimicrobials are as effective against CRPK as they have been demonstrated to
be against other multi-drug resistant forms of the Klebsiella pathogen.
I’ll
report further on this topic as new developments arise.
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Important Note and Disclaimer: The contents of this Ezine have not been evaluated by the Food and Drug Administration. Information conveyed herein is from sources deemed to be accurate and reliable, but no guarantee can be made in regards to the accuracy and reliability thereof. The author, Steve Barwick, is a natural health journalist with over 30 years of experience writing professionally about natural health topics. He is not a doctor. Therefore, nothing stated in this Ezine should be construed as prescriptive in nature, nor is any part of this Ezine meant to be considered a substitute for professional medical advice. Nothing reported herein is intended to diagnose, treat, cure or prevent any disease. The author is simply reporting in journalistic fashion what he has learned during the past 17 years of journalistic research into colloidal silver and its usage. Therefore, the information and data presented should be considered for informational purposes only, and approached with caution. Readers should verify for themselves, and to their own satisfaction, from other knowledgeable sources such as their doctor, the accuracy and reliability of all reports, ideas, conclusions, comments and opinions stated herein. All important health care decisions should be made under the guidance and direction of a legitimate, knowledgeable and experienced health care professional. Readers are solely responsible for their choices. The author and publisher disclaim responsibility or liability for any loss or hardship that may be incurred as a result of the use or application of any information included in this Ezine
